Article produced in collaboration with GUNA
Infusional Therapies (IV Therapy) are therapeutic strategies based on the slow intravenous administration of fluids, nutrients, or medications [6].
They are successfully employed across a range of therapeutic areas—from internal medicine to regenerative medicine, from aesthetic medicine to longevity medicine—to enhance the body’s metabolic efficiency, acting on multiple levels (functional and structural) through drug cocktails with primarily anti-inflammatory, detoxifying, anti-degenerative, energy-metabolism-boosting, antioxidant, and neuroendocrine-balancing activities [4,7].
Infusional therapies may also involve solutions designed to correct nutritional deficiencies, for example through combinations of vitamins, amino acids, and minerals [6].
The great advantage offered by infusion therapies is undoubtedly their high bioavailability: infusion therapy ensures high absorption, immediate action, and the ability to achieve precise dosing, in addition to rapid onset [7,8]; infusion therapy is used, for instance, when the goal is to modulate one or more dysregulated networks in a targeted way, as occurs in Bioregulatory System Medicine (BrSM), the medical approach that uses low-dose multicomponent drugs which, thanks to their characteristics, are well-suited for use even in long-term therapies [1].
But not to be overlooked is also the possibility of personalization (precision medicine) it offers: infusion therapy enables the use of differentiated therapeutic cocktails based on the patient’s clinical history, diagnosis, and, if applicable, analysis of instrumental and laboratory tests, facilitating the development of a tailored treatment plan for each patient [3,6].
The scope of application of infusion therapies is broad [4,9]:
Longevity Medicine Between Bioregulation and Regeneration
Metabolic diseases
- Metabolic disorders
- Chronic and degenerative diseases
- Cardiovascular diseases
- Neurological diseases
- Anxious-depressive syndromes
- Chronic fatigue syndromes
- Non-specific chronic pain syndromes
- Immune system enhancement
- Total Body Detox Therapy
- Cognitive decline
- Support for energetic metabolism
- General well-being and anti-aging
- Improved athletic performance
- LONGEVITY
In recent years, in the IV Therapy field, the model of Bioregulatory Systems Medicine (BrSM) has gained prominence. It uses natural multicomponent low-dose medications that are specifically authorized for intravenous use. The BrSM methodological framework focuses action on restoring homeostasis and regulating dysregulated functional networks, addressing the root etiopathogenic causes of pathology while also targeting emerging symptomatic manifestations [1].
BrSM is also employed in chronic and complex conditions typical of elderly patients, those who are poly-treated and with multi/morbidities, and it enables dynamically tailoring therapy in line with good clinical practice, following systematic outcome monitoring, potentially integrating with other therapies as needed [6,9].
Longevity Medicine, alongside bioregulation and regeneration
One of the medical fields most actively explored in recent years within infusion medicine is undoubtedly Longevity Medicine. Defined as advanced, personalized preventive medicine based on identifying deep aging biomarkers and aimed at supporting or restoring the system’s resilience and robustness, longevity medicine seeks to extend the healthspan and not only the lifespan [2,3].
Longevity Medicine presents itself as a holistic approach to the patient, with a diagnostic phase that relies on (but is not limited to) genomics, advanced imaging, biomarkers (epigenetic, inflammatory, metabolically energetic) and predictive models to identify vulnerabilities, pre-disease states, and risk of premature mortality in apparently healthy individuals [2,3].
Preventing chronic disease, optimizing performance, and increasing the individual’s resilience are the main therapeutic goals of Longevity Medicine [3].
Tangential to Longevity Medicine is Regenerative Medicine, which, although distinct, can coexist with it—for example in circumstances where it is necessary to initiate and sustain tissue repair and regeneration mechanisms. This is the case, for instance, with certain advanced aesthetic medicine treatments.
The Bioregulatory Systems Medicine paradigm represents a tool for Longevity Medicine that aims to offer individuals a valid response to the question of well-being—physical, mental, and emotional—embodying the ideal convergence of bio-regulation and regenerative capacity [1].
The integration of infusion therapies into clinical practice offers physicians a tangible opportunity for professional growth, through the development of therapeutic pathways, improved management of complex patients with multi-morbidity, and the provision of therapeutic responses to new health demands (prevention, performance enhancement, and functional recovery) [3,6].
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Bibliography:
- Goldman AW, Burmeister Y, Cesnulevicius K, et al. Bioregulatory systems medicine: an innovative approach to integrating the science of molecular networks, inflammation, and systems biology with the patient’s autoregulatory capacity. Frontiers in Physiology. 2015;6:225. DOI: 10.3389/fphys.2015.00225
- Tao X, Zhu Z, Wang L, et al. Biomarkers of Aging and Relevant Evaluation Techniques: A Comprehensive Review. Aging and Disease. 2024;15(3):977–1005. DOI: 10.14336/AD.2023.00808
- Moqri M, Herzog C, Poganik JR, et al. Biomarkers of aging for the identification and evaluation of longevity interventions. Cell. 2023;186(18):3758–3775. DOI: 10.1016/j.cell.2023.08.057
- Godic A, Townsend J. Intravenous longevity therapy: a critical review of evidence, mechanisms, and clinical utility Acta Dermatovenerologica APA. 2026. DOI: 10.15570/actaapa.2026.8
- Tyshkovskiy A, Ma S, Shindyapina AV, et al. Distinct longevity mechanisms across and within species and their association with aging. Cell. 2023;186(13):2929–2949.e20. DOI: 10.1016/j.cell.2023.05.002
- Wells C, Butcher R, McCormack S. Intravenous Multivitamin Therapy Use in Hospital or Outpatient Settings: A Review of Clinical Effectiveness and Guidelines, CADTH Rapid Response Report. Ottawa: Canadian Agency for Drugs and Technologies in Health; 2020.
- Alangari A. To IV or Not to IV: The Science Behind Intravenous Vitamin Therapy, Cureus. 2025;17(6):e86527. DOI: 10.7759/cureus.86527
- Alangari A, Arif J, Al Qureshah F, et al. Clinical benefits and risks of high-dose intravenous vitamin C: a systematic review, Journal of Medicine and Life. 2026;19(1):16–23. DOI: 10.25122/jml-2025-017
- Karasiewicz M, Lipiak A, Jóźwiak P, et al. Health Professionals’ Perspectives on Commercially Available Intravenous Nutrient Therapies: A Preliminary Report, Healthcare (Basel). 2024;12(3):386. DOI: 10.3390/healthcare12030386
Abbonati a Karla Miller
